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:: Volume 21, Issue 2 (7-2019) ::
J Gorgan Univ Med Sci 2019, 21(2): 9-17 Back to browse issues page
Effect of combined Atorvastatin and zinc oxide on the biochemical and histopathological alterations in kidney of diabetic rats
Zahra Karampour Gebchag1 , Reza Heidari * 2, Seyyed Meysam Abtahi-Froushani3 , Farah Farokhi4
1- M.Sc in Biochemistry, Department of Biology, Faculty of Science, Urmia University, Urmia, Iran
2- Professor, Department of Biology, Faculty of Science, Urmia University, Urmia, Iran , r.heidari@urmia.ac.ir
3- Assistant Professor, Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
4- Associate Professor, Department of Biology, Faculty of Science, Urmia University, Urmia, Iran
Abstract:   (7377 Views)

Background and Objective: Diabetic mellitus nephropathy is one of the most important implication factors in kidney´s physiological function in diabetes mellitus. Having major role in filtration, in hyperglycemic condition kidney has shown more damages in comparison with other tissues. This study was done to determine the effect of combined Atorvastatin and Zinc oxide on the biochemical and histopathological alterations in kidney of diabetic rats.

Methods: In this experimental study, 40 female Wistar rats were randomly allocated into five groups including normal control (NC), diabetic control (DC), diabetic rats treated with atorvastatin (20mg/kg/bw daily, orally) (D+A), Zinc oxide (30mg/kg/bw daily, orally) (D+Z) and combination of each drug in half dose (daily, orally) (D+A+Z). Diabetes induced in rats by a single intraperitoneal injection of 60mg/kg/bw streptozotocin-diabetic.Animals treated for one month. At the end of the study, kidney weight and body weight and biochemical factors including creatinine and urea were measured to assess renal function. For determing the histopathology of kidney tissue, sections with 4-5 micrometer were stained with hematoxylin and eosin.

Results: The level of serum creatinine and urea was significantly increased in diabetic rats in compare to controls (P<0.05). Treatment of diabetic rats with half doses of combination of atorvastatin and Zinc oxide reduced the level of creatinine, urea and renal tissue damage in comparision with diabetic rats without treatment (P<0.05).

Conclusion: This study showed that the combination of atorvastatin and Zinc oxide has effect on controlling diabetic nephropathy.
Keywords: Diabetes mellitus, Diabetic nephropathy, Atorvastatin, Zinc oxide, Rat
Full-Text [PDF 474 kb]   (20944 Downloads)    
Type of Study: Original Articles | Subject: Physiology - Pharmacology
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Karampour Gebchag Z, Heidari R, Abtahi-Froushani S M, Farokhi F. Effect of combined Atorvastatin and zinc oxide on the biochemical and histopathological alterations in kidney of diabetic rats. J Gorgan Univ Med Sci 2019; 21 (2) :9-17
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Volume 21, Issue 2 (7-2019) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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