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Background & Objective: In addition to pyramidal neurons and interneurons, the hippocampus contains Astrocytes that play important roles in regulating ion flux currents, energy production, neurotransmitter release and memory. Learning needs some instrument for information storage and information maintenances mechanisms resemble to memory. The aim of this study was determination of spatial memory effect on the number of astrocytes in rat’s hippocampus. Materials & Methods: In this experimental study, with usage of Morris Water Maze and Reference memory technique, we used 10 male albino wistar rats. 5 rats were in control group and 5 rats in Reference memory group. After histological preparation, the slides were stained with PTAH staining for showing the Astrocytes. Results: The findings of this study showed significant difference in astrocytes number in CA1, CA2 and CA3 area of hippocampus between control and reference memory group. The mean and SD of astrocytes in CA1, CA2 and CA3 of reference memory group were 118.57±25.29, 58.91±23.59 and 116.6±31.14, that they are more than control group with 49±17.29 in CA1, 48.8±25.21 in CA2 and 41.95±11.22 in CA3. Conclusion: We concluded that the number of astrocytes increased due to spatial learning (e.g. reference memory method).

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Background and Objective: Dentate gyrus is a part of hippocampal formation that plays an important role in memory and learning. Astrocytes are one of the important glial cells in nervous tissue that play a more active role in neuronal activity, including regulating ion flux currents, energy production, neurotransmitter release, and synaptogenesis. The aim of this study was to determine the spatial memory effect on the number of astrocytes in Rat’s dentate gyrus. Materials and Methods: This experimental study, was done on 18 male Wistar Rats with using Morris water maze and Reference and Working memory methods. After spatial learning the Rat's brains was carried out and histological preparation was carried out, the slices were with PTAH method. The data analyzed, using T-test and One-way ANOVA. Results: The results showed significant difference in astrocytes number in dentate gyrus area between Reference memory (300.57±5.98) and control (73.73±22.61) groups (P<0.05). The difference between working memory (375.77±4.11) and control groups was significant. Comparing two groups there was a significant difference of number of astrocytes cell between the working memory and Reference memory group (P<0.05). Conclusion: This study showed that spatial learning such as Reference memory and Working memory increase the number of astrocytes in dentate gyrus and this increase can be due to duration of learning.

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Background and Objective: Genu varus is a deformity in frontal plane that in weight bearing position whiles the medial malleolus’s touch each other, the medial knee epicondyles far from each other. Genu varus is very prevalent in soccer players. This study was done to evaluate the effect of using knee brace and lateral wedge on muscular activity amplitude in male soccer players with genu varus during running.
Methods: This quasi-experimental study was done on 15 right-footed male soccer players with genu varus and 15 healthy soccer players. A wireless electromyography system with eight pairs of bipolar Ag/AgCl surface electrodes (20 mm center-to-center distance; input impedance of 100 MΩ; and common-mode rejection ratio of >110 dB) was used to record the activity of the tibialis anterior, gastrocnemius medialis, biceps femoris, semitendinosus, vastus lateralis, vastus medialis, and rectus femoris, and gluteus medius muscles of the right leg. Electromyography data were recorded by sampling rate of 1000 Hz in selected muscles during running at five conditions including: control, 10 degrees lateral wedge, 15 degrees lateral wedge, simultaneous using 30 degrees brace and 10 degrees lateral wedge, and simultaneous using 30 degree brace and 15 degrees lateral wedge.
Results: Treatment intervention had reduction effect on muscular amplitude of biceps femoris and vastus lateralis during push-off phase (P<0.05). Muscular amplitude of biceps femoris and vastus lateralis during loading phase was reduced due to Treatment intervention (P<0.05).
Conclusion: Simultaneous using of lateral wedge and knee brace reduce the electromyography activity of vastus lateralis and biceps femoris muscles. This reduction may be associated with passive support of knee brace that in result could decrease the external knee adductor mowment.