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In this case-control study, 58 transfusion-dependent Thalassemic patients compared with 46 normal healthy persons on study of their thyroid size & function. In this study, thalassemia patients divided in two groups: Group one 31 patients with (Ferritin<1500) and group two 27 patients with (Ferritin>1500) and 3rd one was named control group (46 healthy persons). These groups were compared to achieve the best possible results and conclusion out of 31 patients. From first group 26 people had normal thyroid function test only 5 patients (16%) had goiter. From 27 patients in second group, 5 people (19%) had normal thyroid and 22 patients had goiter, in 3rd group 29% had normal thyroid, the difference between second and third groups were significant (P<0.01). In second group T4 level were lower than control, instead the TSH level were more than control group. The difference in second and third group were significant. The mean of T3 and T4 in group one and three don’t have significant differences. Conclusion: The goiter incidence and hypothyroidism in major Thalassemia with poor control (Ferritin>1500) are high.

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The term Noonan syndrome has been applied to phenotypic male and female who have certain anomalies that occur also in female with Turner’s syndrome. These patients have normal karyotype. The disorder is very rare. The most common abnormality are short stature, webbing of the neck, Pectus Carinatum or Pectus excavatum, congenital heart disease. This particular case is a 8-year-old girl-patient who referred to pediatric clinic with short stature. Another abnormality in these patients is abnormal facies (Hypertelorism, hypogonadism, piqure chest and webbing of the neck). The patient had moderate mental retardation. Chromosomal analysis revealed 46xx cytogenetic distinguished Noonan syndrome.

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Background and Objective: The metabolic syndrome is a cluster of metabolic disorders that are associated with elevated risk of cardiovascular diseases and type-II diabetes. This study investigated the prevalence of metabolic syndrome among adolescents population in Gorgan, Northern Iran - 2009.

Materials and Methods: A cross-sectional survey was conducted involving 450 adolescents 15-17 years, selected through 2 stage cluster randomized sampling from high schools. Anthropometric measurements, blood pressure, fasting blood glucose and lipid profile were assessed. Metabolic syndrome was defined according to NHANES III criteria. Data was analyzed by SPSS-16 software, Chi-Square and logestic regration.

Results: The overall metabolic syndrome prevalence was 3.3% (CI 95%:1.8–5.4). More than half of cases (54.6%) had at least 1 or 2 components. High triglyceride level was the most common disorder in both genders (boys 27.6%, girls 52.4%) and then low HDL cholesterol level (17.3%) and central obesity (7.6%) were common among boys and girls respectively. Where as abdominal obesity in boys (0.9%) and hypertension in girls (3.1%) were less common.

Conclusion: This study showed that the rate of metabolic syndrome is slightly lower but the obsity in adolescents is higher than other parts of country.