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Background&Objective: The breast cancer is the most common malignancy in women. The normal and malignant breast tissue are under the regulatory effects of esteroid hormones and growth factors including HER-2/neu. The purpose of this study, is to determine the expression of estrogene receptor (ER) progesterone receptor(PR) and HER-2/neu among Iranian women with invasive breast cancer. Materials&Methods: The study is descriptive and cross-sectional that was performed on 50 samples of patients with invasive breast cancer in Imam-Khomeini Hospital-Sari (2005-06). After preparing the samples four tissue sections from each sample was obtained then H&E and IHC staining were performed. Results: In our study, the patients were between 28-88 yrs, (mean:52/6). ER and PR and HER-2/neu were positive in 80%, 72% and 57.1% of cases, respectively. Concurrent positive ER and PR was 70%, meanwhile 62.9% of these patient were also positive for HER-2/neu. 20% of the cases showed negativity for both ER and PR and of these 83.4% were also negative for HER-2/neu. Conclusion: In our study ER expression by itself is equal to previous studies in textbooks but PR expression, HER-2/neu and concurrent expression of ER&PR are higher in our study. Interestingly HER-2/neu expression is near to what was previously proposed by Iranian Blood Transfusion Organization and Kerman University of Medical science. It seems that racial and geographic factors are contributed for these diffrences.

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Background and Objective: Several studies have shown that high level of Endothelin-1 and Malondialdehyde lead to an increase in the risk of coronary artery diseases. This study was done to evaluate the effect of aerobic training on Endothelin-1 and Malondialdehyde in inactive elderly women.

Methods: In this quasi -experimental study, 21 inactive elderly women with range of 60-70 year non-randomly divided into experimental (n=11) and control (n=10) groups. The aerobic training including eight weeks aerobic training (with intensity of 50-70 percent of reserve heart rate), 3 times a week, and 60 minutes per session. Endothelin-1 and Malondialdehyde were measured at baseline and at the end of the study.

Results: After eight weeks of aerobic exercise, Endothelin-1 level reduced in intervention group (35.96%) and control group (41.09%) (P<0.05). After eight weeks of aerobic exercise there was no significat difference between intervention and control groups. After eight weeks of aerobic exercise reduce of Malondialdehyde level in intervention and control groups was not significant difference.

Conclusion: Regarding to reducing the serum level of Endothelin-1 in in the control and experimental groups, the aerobic training with moderate intensity did not lead to reduce in levels of serum Endothelin-1 in elderly women.