[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
About the Journal
Aims and Scope
Content Coverage
Conflict of Interest
Publication Ethics
Editorial Board::
Executive Members::
Instruction to Authors::
Peer Review::
Articles Archive::
Current Issue
All Issues
Indexing Databases::
Contact Us::
Contact Us
Contact Form
Site Facilities::
Search contents
::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 18, Issue 4 (12-2016) ::
J Gorgan Univ Med Sci 2016, 18(4): 30-35 Back to browse issues page
Effect of Echinophora-platyloba extract on the pituitary-thyroid axis and lipid profile in hypercholesterolemic rats
M Khosravizad1 , A Zarei * 2, MA Chobineh3 , F Karimi4 , Z Sadeghpour4 , Z Karimi4 , S Baradaran4 , A Sharashob4
1- Academic Instructor, Department of Nursing, Abadeh Branch, Islamic Azad University, Abadeh, Iran
2- Ph.D in Physiology, Department of Physiology, Abadeh Branch, Islamic Azad University, Abadeh, Iran , zarei.ali@iauabadeh.ac.ir
3- M.Sc in Physiology, Department of Physiology, Abadeh Branch, Islamic Azad University, Abadeh, Iran
4- B.Sc Student in Nursing, Abadeh Branch, Islamic Azad University, Abadeh, Iran
Abstract:   (14279 Views)

Background and Objective: Hyperlipidemia can be considered as one of the main risk factor, involved in cardiovascular disease and it is a major cause of death. This study was done to determine the effect of air part of Echinophora platyloba extract on Pituitary - thyroid axis hormones and lipid profile in hypercholesterolemic rats.

Methods: In this experimental study, 40 male Wistar rats were randomly allocated into 5 groups (n=8) including control group with normal diet, hypercholesterolemic group along with high cholesterol diet, and the three treatment groups with hypercholesterolemia which animals were received daily doses of 100, 200 and 300 mg/kg/bw of the hydroalcoholic extract of Echinophora platyloba, respectively by gavage during 42 days. At the end of this period, blood sample was obtained. Lipid profile, including total cholesterol, triglycerides (TG), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), high density lipoprotein (HDL), triiodothyronine (T3), thyroxine (T4) and thyroid hormone stimulation (TSH) were measeared using Radioimnoassay method.

Results: The level of LDL and cholesterol and TG, significantly reduced in treated group receiving the lowest dose of the extract (100 mg/kg/bw) in compare to hypercholesterolemic group (P<0.05). The level of HDL, TSH and T4 significantly increased in the treated group receiving the highest doses of the extract (300 mg/kg/bw) in compare to hypercholesterolemic group (P<0.05).

Conclusion: Echinophora platyloba extract dose dependly can alter Pituitary- thyroid axis hormones and lipid profile in hypercholesterolemic rats.
Keywords: Echinophora Platyloba, hypercholesterolemia, Thyroid hormone, Lipid profile, Rat
Full-Text [PDF 191 kb] [English Abstract]   (20936 Downloads) |   |   Abstract (HTML)  (1560 Views)  
Type of Study: Original Articles | Subject: Physiology - Pharmacology
References
1. Salam DA, Surya AS, Dawn VT, Carla B, Kumar A, Sunil C. A review of hyperlipidemia and medicinal plants. Int J A PS BMS. 2013; 2(4): 219-37.
2. Majdi MR, Nickparast N, Bagherzadeh A, Puradine M, SaberyKarimian M, Khani H, et al. [The prevalence of hyperlipidemia and some effective factors in teachers of North Khorasan Province]. J North Khorasan Uni Med Sci. 2012; 4(1): 67-78. [Article in Persian]
3. Alagumanivasagam G, Veeramani P. A review on medicinal plants with hypolipidemic activity. International Journal of Pharmacy and Analytical Research. 2015; 4(2): 129-34.
4. Khazai V, Piri KH, Nazeri S, Karamian R, Zamani N. Free radical scavenging activity and phenolic and flavonoid contents of Echinophora Platyloba DC. Asian J Med Pharm Res. 2011; 1(1): 9-11.
5. Heidarian E, Saffari J, Jafari-Dehkordi E. Hepatoprotective action of Echinophora platyloba DC leaves against acute toxicity of acetaminophen in rats. J Diet Suppl. 2014 Mar; 11(1): 53-63. doi:10.3109/19390211.2013.859217
6. Changizi-Ashtiyani S, Zarei A, Taheri S, Rasekh F, Ramazani M. [The effects of Portulaca Oleracea alcoholic extract on induced hypercholesteroleomia in rats]. Zahedan J Res Med Sci. 2013; 15(6): 34-39. [Article in Persian]
7. Mirghazanfari SM, Hosseinzadeh L, Shokoohinia Y, Aslany M, Kamali-Nejad M. Acute and subchronic toxicological evaluation of Echinophora platyloba DC (Apiaceae) total extract in Wistar rats. Clinics (Sao Paulo). 2012 May; 67(5): 497-502. doi:10.6061/clinics/2012(05)15
8. Ogbunugafor HA, Eneh FU, Ozumba AN, Igwo-Ezikpe MN, Okpuzor J, Igwilo IO, et al. Physico-chemical and antioxidant properties of Moringa oleifera Seed Oil. Pakistan Journal of Nutrition. 2011; 10(5): 409-14. doi:10.3923/pjn.2011.409.414
9. Mukarram Shah SM, Hassan Shah SM. Phytochemicals, antioxidant, antinociceptive and anti-inflammatory potential of the aqueous extract of Teucrium stocksianum bioss. BMC Complementary and Alternative Medicine. 2015; 15: 351. doi:10.1186/s12906-015-0872-4
10. Heidarian E, Saffari J, Jafari-Dehkordi E. Hepatoprotective action of Echinophora platyloba DC leaves against acute toxicity of acetaminophen in rats. J Diet Suppl. 2014 Mar; 11(1): 53-63. doi:10.3109/19390211.2013.859217
11. Shahneh FZ, Baradaran B, Majidi J, Babaloo Z. Echinophora platyloba DC (Apiaceae) crude extract induces apoptosis in human prostate adenocarcinoma cells (PC 3). Biomed J. 2014 Sep-Oct; 37(5): 298-304. doi:10.4103/2319-4170.125653
12. Keaney JF Jr, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, et al. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham study. Arterioscler Thromb Vasc Biol. 2003 Mar; 23(3): 434-9.
13. Hussain SP, Hofseth LJ, Harris CC. Radical causes of cancer. Nat Rev Cancer. 2003 Apr; 3(4): 276-85.
14. Oben JE, Enyegue DM, Fomekong GI, Soukontoua YB, Agbor GA. The effect of Cissusquadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress. Lipids Health Dis. 2007; 6:4.
15. van Heerden FR. Hoodia gordonii: a natural appetite suppressant. J Ethnopharmacol. 2008 Oct; 119(3): 434-7.
16. Zarei A, Changizi Ashtiyani S, Sokhandani M, Rezaei A, Zaheiri S, Taheri S. Comparison between the effects of the alcholic extract of Mellissia Officinalis and atorvastatin on serum levels of thyroid hormones in hypercholesterolemic male rats. Zahedan J Res Med Sci. 2013 Aug; 15(8): 6-12.
17. Pourjafar M, Mohebbi A, Nazifi S, Tarakeme Samani S. [In vitro study of effect of high-fat diet on serum leptin and thyroid hormone levels in mice]. J Shaheed Sadoughi Univ Med Sci. 2010; 18(5): 428-35. [Article in Persian]
18. Moshtaghi-Kashanian GhR, Gholamhoseinian A, Sanjari M, Kor M. [Evaluation of Ghrelin and Leptin in patients with thyroid malfunction]. J Kerman Univ Med Sci. 2005; 12(4): 219-27.
19. Sowmya A, Ananthi T. Hypolipidemic activity of Mimosa pudicaLinn on butter induced hyperlipidemia in rats. Asian J Res Pharm Sci. 2011; 1(4): 123-26.
Send email to the article author

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Khosravizad M, Zarei A, Chobineh M, Karimi F, Sadeghpour Z, Karimi Z, et al . Effect of Echinophora-platyloba extract on the pituitary-thyroid axis and lipid profile in hypercholesterolemic rats. J Gorgan Univ Med Sci 2016; 18 (4) :30-35
URL: http://goums.ac.ir/journal/article-1-2952-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 18, Issue 4 (12-2016) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
Persian site map - English site map - Created in 0.04 seconds with 36 queries by YEKTAWEB 4679
Creative Commons License
This work is licensed under a Creative Commons — Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)